General Cell Lines and Cell Cultures
Cayman Chemical BRD4 bromodomaIn 1 TRFRET384
A Dyrk1a and Gsk3B inhibitor (IC50s 6 and 16 nM respectively for the mouse enzymes) selective for Dyrk1a and Gsk3B over a panel of 57 kinases but does inhibit 10 other kinases at 1 UM increases the proliferation of R7T1 mouse pancreatic B-cells and primary human pancreatic B-cells (EC50s 0.66 and 0.54 UM respectively) increases the number of islet and B-cells and the levels of total DNA and ATP in primary human islet cells at 2 UM increases the proliferation of transplanted primary human islet cells and decreases the levels of blood glucose in mice at 50 mg/kg twice per day reduces the levels of blood glucose in an OGTT in a transgenic RIP-DTA mouse model of type I diabetes at 50 mg/kg twice per day increases the mass of and levels of insulin in pancreatic B-cells in the same mice
Abeomics Nrf2 Reporter Mcf7 Cell Line
The Nrf2 Leeporter Luciferase Reporter cell line is a stably transfected MCF7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the antioxidant response element (ARE). ARE is known to regulate expression and induction of various detoxifying enzyme genes in response to antioxidants and xenobiotics, and is primarily regulated by the Keap1-Nrf2 pathway in which induction and nuclear translocation of Nrf2 mediated by antioxidants and xenobiotics results in the binding of Nrf2 to ARE leading to the expression of defensive genes. Cell line application: (1) Monitor the Nrf2 induction activity, and (2) Screen for activators or inhibitors of the Nrf2 signaling pathway. .
StemExpress Peripheral Blood CD14+ Monocytes, Frozen, 10 million/vial
Human peripheral blood CD14+ monocytes are isolated from the mononuclear cell fraction by means of negative selection. Isolated cells are characterized by flow cytometry to ensure a highly pure and viable cell population.
ABclonal Technology ADORA2A Rabbit pAb
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily, specifically an A2A adenosine receptor. It responds to adenosine, activating G(s) and G(olf) proteins to increase intracellular cAMP levels. The receptor plays key roles in regulating cardiac rhythm, circulation, cerebral and renal blood flow, immune function, pain, and sleep. It is involved in conditions like inflammatory diseases and neurodegenerative disorders. Alternative splicing produces multiple transcript variants, including a read-through transcript with the upstream SPECC1L gene, thought to be non-coding.
Genscript Corporation CHO-K1/NK2 Stable Cell Line
Tachykinins are peptides sharing a common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH sub 2 /sub This neuropeptide family is composed of substance P neurokinin A and neurokinin B which are widely distributed in mammalian central and peripheral nervous systems These three molecules serve as both neurotransmitters and neuromodulators Their actions are mediated by binding with three distinct receptors namely NK1 NK2 and NK3 In particular NK2 is expressed in gastrointestinal tract Activation of NK2 is chiefly responsible for the regulation of intestinal motor functions (both excitatory and inhibitory) secretions inflammation and visceral sensitivity Antagonists of NK2 may be useful in the treatment of irritable bowel syndrome
Genscript Corporation CHO-K1/G15/AMY2 Stable Cell L
Receptor activity-modifying proteins (RAMPs) are a class of protein which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin calcitonin (CT) glucagon and vasoactive intestinal peptide (VIP) There are three distinct types of RAMPs designated RAMP1 RAMP2 and RAMP3 each encoded by a separate gene Currently the function of RAMPs is divided into 2 class activities Association of RAMPs with either the CT or CALCR proteins forms 6 different receptors from the calcitonin receptor family When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) RAMPs can change the selectivity of the receptor for a specific hormone In the cases of the other receptors mentioned however there is no evidence that they can do this but instead function to regulate trafficking of receptors from the ER / golgi to the membrane GenScript s cloned human AMY2 (RAMP2 CALCR) expressing cell line is gen
Cell Applications Inc Rat Midbrain Neurons Total Kit
Rat Midbrain Neurons Total Kit:(R8810N-10) Cryopreserved (RMbN), 1 vial(R817-100) Rat Neuron Culture Media, 100ml(027-05) Neuron Coating Solution I, 5ml(R817P-10) Neuron Plating Solution, 10ml
Genscript Corporation CHO-K1/FFA1/G15 Stable Cell L
Recombinant CHO-K1 cells stably overexpress human free fatty acid receptor 1 (FFA1) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/BTLA Stable Cell Line
The B and T lymphocyte attenuator (BTLA) is an Ig super family protein with an intermediate type Ig fold in the ectodomain and an ITIM inhibitory signaling domain in the cytosol BTLA interacts with the herpesvirus entry mediator (HVEM TNFRSF14) a TNFR super family member Engagement of BTLA by HVEM induces tyrosine phosphorylation of the ITIM motifs in the cytoplasmic tail of BTLA allowing the recruitment of the phosphatases SHP-1 and SHP-2 which attenuate signaling
Genscript Corporation CHO-K1/OPRL1/G15 Stable Cell
Following the cloning of the classical opioid receptors (mu delta and kappa) the opiate receptor like-1 (ORL1) was identified as a G-protein coupled receptor (GPCR) with 65% structure homology to the other members of the opioid family OPRL1 is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ and may be involved in the regulation of numerous brain activities particularly instinctive and emotional behaviors Recently new study results are consistent with the reported high density of ORL1 receptor mRNA in dorsal raphe nucleus and with inhibitory actions of nociceptin in cells expressing ORL1